Piriformis Syndrome is an entrapment neuropathy in which a tight and/or inflamed piriformis muscle compresses the sciatic nerve, the largest nerve in the body, producing radicular type of symptoms. There are many causes of this problem from altered foot biomechanics to poor hip joint function. Prolonged sitting and exercises that promote hip flexion and extension repetitively can create these symptoms. Although this mimics sciatica, caused by a lumbar disc bulge or herniation, this syndrome is quite different in that the source of pain is the deep gluteal muscle, not the spine. There may, however be instances where a patient has both a spine issue and/or a piriformis syndrome. Once identified correctly, this can be treated conservatively with excellent outcomes.